Discover and benefit from a promising area of health care
There is compelling evidence that many of the risks leading to the most frequent chronic diseases in adulthood originate in the earliest stages of life. Adverse environmental conditions in utero and during infancy can lead to negative health effects during the subsequent lifetime of the exposed individual.
This book offers precious insights into the latest concepts and results from epidemiologic, clinical and basic studies in this burgeoning area of health care. The developmental origins of various diseases such as diabetes, obesity and cancer are examined, as well as the early programming of reproductive health and different organs. Attention is given to the impact of environmental factors such as nutrition and pollution, and the mediating genetic and epigenetic pathways are reviewed. A crucial point under discussion is the concept of environmental insults adversely affecting not only the exposed persons, but also their descendants. In addition, the economic consequences of a suboptimal start to life and the importance of preventive measures are stressed.
This publication is of great value to anyone interested in health care, notably to specialists in obstetrics, pediatrics, internal medicine, obesity, diabetes and heart disease.
Early Life Origins of Human Health and Disease
Special Section
I Title Page / List of Contents / Preface / Abbreviations
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp I–IX
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Paper
1 Developmental Plasticity and the Developmental Origins of Health and Disease
Gluckman, P.D. ; Hanson, M.A.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 1–10
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11 Epigenetics and the Influence of Maternal Diet
Lillycrop, K.A. ; Hanson, M.A. ; Burdge, G.C.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 11–20
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21 The Economics of Developmental Origins of Health and Disease: Modelling the Benefit of a Healthy Start to Life
Franko, K.L. ; O'Connor, K.C. ; Morton, S.M.B.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 21–28
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29 Nutritional Interventions in Mothers to Improve the Health of the Offspring - Are We Ready?
Fall, C.H.D. ; Harding, J.E. ; Yajnik, C.S.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 29–41
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42 Developmental Origins of Health and Disease: The Importance of Environmental Exposures
Newbold, R. ; Heindel, J.J.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 42–51
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52 Developmental Origins of Health and Disease across Generations - Theory, Observation, Experiment
Gillman, M.W. ; Smith, G.D. ; Hanson, M.A. ; Spencer, H.G.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 52–64
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65 Early Embryo Environment and Developmental Potential
Fleming, T.P. ; Sinclair, K.D. ; Kind, K.L.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 65–77
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78 Early Environmental Influences on Lung Development: Implications for Lung Function and Respiratory Health throughout Life
Harding, R. ; Snibson, K. ; O'Reilly, M. ; Maritz, G.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 78–88
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89 Development of the Fetal Hypothalamic-Pituitary-Adrenal-Placental Axis: Implications for Postnatal Health
Challis, J. ; Connor, K. ; Matthews, S. ; Lye, S.J. ; Caniggia, I. ; Petraglia, F. ; Imperatore, A. ; Sloboda, D.M. ; Li, S. ; Braun, T. ; Li, W. ; Newnham, J.P.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 89–99
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100 Developmental Origins of Musculoskeletal Disease
Cooper, C. ; Sayer, A.A. ; Mishra, G. ; Kuh, D.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 100–112
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113 Developmental Origins of Reproductive Health
Sloboda, D.M. ; Hart, R. ; Hickey, M.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 113–122
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123 Developmental Origins of Immune Tolerance: Pathways and Influences
Prescott, S.L.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 123–132
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133 Developmental Programming of the Kidney
Nijland, M.J. ; Nathanielsz, P.W.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 133–141
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142 Perinatal Appetite Programming
Desai, M. ; Keen-Rhinehart, E. ; Ross, M.G.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 142–163
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164 Fetal Programming of Type 2 Diabetes
Piekarz, A. ; Ozanne, S.E.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 164–173
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174 Developmental Origins of Diabetes: Interventional Strategies
Simmons, R.A.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 174–183
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184 Prenatal Risk Factors for Breast Cancer and Clues to the Underlying Biological Mechanisms from Animal and Human Studies
Troisi, R. ; dos Santos Silva, I.. ; Newbold, R.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 184–192
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193 The Offspring of Women with Severe Mental Disorder
Morgan, V.A. ; McGrath, J. ; Hultman, C.M. ; Zubrick, S. ; Bower, C. ; Croft, M. ; Valuri, G. ; Jablensky, A.V.
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 193–204
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205 Approaches to Evaluate Gene-Environment Interactions Underlying the Developmental Origins of Health and Disease
Pennell, C.E. ; Palmer, L.J. ; Knight, B.S. ; Relton, C. ; Lye, S.J. ;
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 205–217
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Further Section
218 Author Index
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 218
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219 Subject Index
Newnham JP, Ross MG (eds): Early Life Origins of Human Health and Disease. Basel, Karger, 2009, pp 219-224
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